Heartland Assays

Animal Nutrition

2019

Thayer TT, Nelssen JL, Langemeier JA, et al. 2019

The effects of maternal dietary supplementation of cholecalciferol (vitamin D3) and 25(OH)D3 on sow and progeny performance. Translational Animal Science, Volume 3, Issue 2, March 2019.
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2018

Olds J, Oltman W, Makowski AJ, Householder H, Keeley LL.

SEASONAL VARIATION OF SERUM 25-HYDROXY-VITAMIN D IN TWO CAPTIVE EASTERN BLACK RHINOCEROS ( DICEROS BICORNIS MICHAELI) HOUSED IN A NORTH AMERICAN ZOO. J Zoo Wildl Med. 2018 Dec;49(4):943-951.
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2017

Weidner N, Woods JP, Conlon P, et al. 2017

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs. J Vet Intern Med, 31: 1796–1803. doi:10.1111/jvim.14834
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Larson-Meyer DE, Ingold BC, Fensterseifer SR, et al. 2017

Sun exposure in pigs increases the vitamin D nutritional quality of pork. PLoS One. 2017 Nov 14;12(11):e0187877. doi: 10.1371/journal.pone.0187877. eCollection 2017.
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2011

Hedberg GE, Derocher AE, Andersen M, Rogers QR, et al. 2011

Milk composition in free-ranging polar bears (Ursus maritimus) as a model for captive rearing milk formula., Zoo Biol 10: zoo.20375
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2010

Nonnecke BJ, Foote MR, Miller BL, Beitz DC, Horst RL., 2010

Short communication: Fat-soluble vitamin and mineral status of milk replacer-fed dairy calves: effect of growth rate during the preruminant period., J Dairy Sci. 93: 2684-90

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Przybylski R, McCune S, Hollis B, Simpson RU

Vitamin D deficiency in the spontaneously hypertensive heart failure [SHHF] prone rat., Nutr Metab Cardiovasc Dis. 20: 641-6
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2009

Chesney RW, Hedberg GE, Rogers QR, et al. 2009

Does taurine deficiency cause metabolic bone disease and rickets in polar bear cubs raised in captivity?, Adv Exp Med Biol. 643: 325-31
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Waters WR, Nonnecke BJ, Gibbs SE, et al. 2009

Serum 25-hydroxyvitamin D concentrations in captive and free-ranging, white-tailed deer (Odocoileus virginianus)., Int J Vitam Nutr Res. 79: 180-7
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2008

Liu N, Nguyen L, Chun RF, et al. 2008

Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation., Endocrinology 149: 4799-808
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2007

Rath NC, Kannan L, Pillai PB, et al. 2007

Evaluation of the efficacy of vitamin D3 or its metabolites on thiram-induced tibial dyschondroplasia in chickens., Res Vet Sci. 83: 244-50
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Hollis BW, Horst RL, 2007

The assessment of circulating 25(OH)D and 1,25(OH)2D: where we are and where we are going., J Steroid Biochem Mol Biol 103: 473-6
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2005

Horst RL, Goff JP, Reinhardt TA, 2005

Adapting to the transition between gestation and lactation: differences between rat, human and dairy cow., J Mammary Gland Biol Neoplasia 10: 141-56
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Bajwa A, Horst RL, Beckman MJ, 2005

Gene profiling the effects of calcium deficiency versus 1,25-dihydroxyvitamin D induced hypercalcemia in rat kidney cortex., Arch Biochem Biophys. 438: 182-94
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Rivera JD, Bachman SE, Hubbert ME, et al. 2005

Short communication: serum and tissue concentrations of vitamin D metabolites in beef heifers after buccal dosing of 25-hydroxyvitamin D3., Dairy Sci. 88: 1364-9
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2004

Montgomery JL, Blanton JR Jr, Horst RL, et al. 2004

Effect of supplemental vitamin D3 concentration on concentrations of calcium, phosphorus, and magnesium relative to protein in subcellular components of the longissimus and the distribution of calcium within longissimus muscle of beef steers., J Anim Sci. 82: 2742-9
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Yuan B, Xing Y, Horst RL, Drezner MK, 2004

Evidence for abnormal translational regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in the hyp-mouse., Endocrinology 145: 3804-12
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Waters WR, Palmer MV, Nonnecke BJ, et al. 2004

Mycobacterium bovis infection of vitamin D-deficient NOS2-/- mice., Microb Pathog 36: 11-7
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2003

Waldron MR, Nonnecke BJ, Nishida T, et al. 2003

Effect of lipopolysaccharide infusion on serum macromineral and vitamin D concentrations in dairy cows., J Dairy Sci. 86: 3440-6
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Horst RL, Goff JP, Reinhardt TA, 2003

Role of vitamin D in calcium homeostasis and its use in prevention of bovine periparturient paresis., Acta Vet Scand Suppl. 97: 35-50
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Waters WR, Nonnecke BJ, Foote MR, et al. 2003

Mycobacterium bovis bacille Calmette-Guerin vaccination of cattle: activation of bovine CD4+ and gamma delta TCR+ cells and modulation by 1,25-dihydroxyvitamin D3., Tuberculosis (Edinb) 83: 287-97
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Nonnecke BJ, Waters WR, Foote MR, et al. 2003

In vitro effects of 1,25-dihydroxyvitamin D3 on interferon-gamma and tumor necrosis factor-alpha secretion by blood leukocytes from young and adult cattle vaccinated with Mycobacte, Int J Vitam Nutr Res 73: 235-44
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Fujiwara I, Aravindan R, Horst RL, Drezner MK, 2003

Abnormal regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in X-linked hypophosphatemia: a translational or post-translational defect., J Bone Miner Res 18: 434-42
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Horst RL, Omdahl JA, Reddy S, 2003

Rat cytochrome P450C24 (CYP24) does not metabolize 1,25-dihydroxyvitamin D2 to calcitroic acid., J Cell Biochem 88: 282-5
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2002

Huff GR, Huff WE, Balog JM, et al. 2002

Effect of dietary supplementation with vitamin D metabolites in an experimental model of turkey osteomyelitis complex., Poult Sci 81: 958-65
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Arjmandi BH, Khalil DA, Hollis BW, 2002

Soy protein: its effects on intestinal calcium transport, serum vitamin D, and insulin-like growth factor-I in vvariectomized rats., Calcif Tissue Int 70: 483-7
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2000

Rao LS, Ray R, Holick MF, et al. 2000

Metabolism of [3alpha-3H] 25-hydroxyvitamin D2 in kidneys isolated from normal and vitamin D2-intoxicated rats., J Nutr Sci Vitaminol (Tokyo) 46: 222-9
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Moore SJ, VandeHaar MJ, Sharma BK, et al. 2000

Effects of altering dietary cation-anion difference on calcium and energy metabolism in peripartum cows., J Dairy Sci. 83: 2095-104
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Horst R, Prapong S, Reinhardt T, et al. 2000

Comparison of the relative effects of 1,24-dihydroxyvitamin D(2) [1, 24-(OH)(2)D(2)], 1,24-dihydroxyvitamin D(3) [1,24-(OH)(2)D(3)], and 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] on selected vitamin D-regulated events in the rat., Biochem Pharmacol 60: 701-8
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Ametaj BN, Nonnecke BJ, Horst RL, Beitz DC, 2000

Effects of retinoic acid and 1,25-dihydroxyvitamin D3 on IFN-gamma secretion by mononuclear leukocytes from nulliparous and postparturient dairy cattle., Int J Vitam Nutr Res 70: 92-101
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1999

Rao DS, Dayal R, Siu-Caldera ML, et al. 1999

Isolation and identification of 4,25-dihydroxyvitamin D2: a novel A-ring hydroxylated metabolite of vitamin D2., J Steroid Biochem Mol Biol 71: 63-70
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1997

Xu T, Leach RM Jr, Hollis B, Soares JH Jr, 1997

Evidence of increased cholecalciferol requirement in chicks with tibial dyschondroplasia., Poult Sci 76: 47-53
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Rajaraman V, Nonnecke BJ, Horst RL, 1997

Effects of replacement of native fat in colostrum and milk with coconut oil on fat-soluble vitamins in serum and immune function in calves., J Dairy Sci 80: 2380-90
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1996

Eppard PJ, Veenhuizen JJ, Cole WJ, et al. 1996

Effect of bovine somatotropin administered to periparturient dairy cows on the incidence of metabolic disease., J Dairy Sci 79: 2170-81
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1995

Knutson JC, Hollis BW, LeVan LW, et al. 1995

Metabolism of 1 alpha-hydroxyvitamin D2 to activated dihydroxyvitamin D 2 metabolites decreases endogenous 1 alpha, 25-dihydroxyvitamin D 3 in rats and monkeys., Endocrinology 136: 4749-53
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Goff JP, Reinhardt TA, Horst RL, 1995

Milk fever and dietary cation-anion balance effects on concentration of vitamin D receptor in tissue of periparturient dairy cows., J Dairy Sci 78: 2388-94
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Goff JP, Horst RL, 1995

Assessing adequacy of cholecalciferol supplementation in chicks using plasma cholecalciferol metabolite concentrations as an indicator., J Nutr 125: 1351-7
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Yarger JG, Quarles CL, Hollis BW, Gray RW., 1995

Safety of 25-hydroxycholecalciferol as a source of cholecalciferol in poultry rations., Poult Sci. 74: 1437-46
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Yarger JG, Saunders CA, McNaughton JL, et al. 1995

Comparison of dietary 25-hydroxycholecalciferol and cholecalciferol in broiler chickens., Poult Sci 74: 1159-67
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1994

Beckman MJ, Goff JP, Reinhardt TA, et al. 1994

In vivo regulation of rat intestinal 24-hydroxylase: potential new role of calcitonin., Endocrinology 135: 1951-5
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Horst RL, Goff JP, Reinhardt TA, 1994

Calcium and vitamin D metabolism in the dairy cow., J Dairy Sci 77: 1936-51
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Reinhardt TA, Horst RL, 1994

Phorbol 12-myristate 13-acetate and 1,25-dihydroxyvitamin D3 regulate 1,25-dihydroxyvitamin D3 receptors synergistically in rat osteosarcoma cells., Mol Cell Endocrinol 101: 159-65
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1991

Kalu DN, Salerno E, Liu CC, et al. 1991

A comparative study of the actions of tamoxifen, estrogen and progesterone in the ovariectomized rat., Bone Miner 15: 109-23
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Goff JP, Reinhardt TA, Horst RL, 1991

Enzymes and factors controlling vitamin D metabolism and action in normal and milk fever cows., J Dairy Sci 74: 4022-32
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Goff JP, Horst RL, Mueller FJ, et al. 1991

Addition of chloride to a prepartal diet high in cations increases 1,25-dihydroxyvitamin D response to hypocalcemia preventing milk fever., J Dairy Sci 74: 3863-71
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1990

Gray RW, Omdahl JL, Ghazarian JG, Horst RL, 1990

Induction of 25-OH-vitamin D3 24- and 23-hydroxylase activities in partially purified renal extracts from pigs given exogenous 1,25-(OH)2D3., Steroids 55: 395-8
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Koszewski NJ, Reinhardt TA, Beitz DC, Horst RL, 1990

Developmental changes in rat kidney 1,25-dihydroxyvitamin D receptor., Biochem Biophys Res Commun 170: 65-72
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Goff JP, Horst RL, 1990

Effect of subcutaneously released 24F-1,25-dihydroxyvitamin D3 on incidence of parturient paresis in dairy cows., J Dairy Sci 73: 406-12
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Horst RL, Goff JP, Reinhardt TA, 1990

Advancing age results in reduction of intestinal and bone 1,25-dihydroxyvitamin D receptor., Endocrinology 126: 1053-7
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Lieuallen WG, Weisbrode SE, Horst RL, Nagode LA, 1990

The effects of uremia and dietary phosphorus on the bone of rats., Bone 11: 41-6
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1989

Reinhardt TA, Horst RL, 1989

Ketoconazole inhibits self-induced metabolism of 1,25-dihydroxyvitamin D3 and amplifies 1,25-dihydroxyvitamin D3 receptor up-regulation in rat osteosarcoma cells., Arch Biochem Biophys 272: 459-65
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Goff JP, Reinhardt TA, Horst RL, 1989

Recurring hypocalcemia of bovine parturient paresis is associated with failure to produce 1,25-dihydroxyvitamin D., Endocrinology 125: 49-53
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Kistler A, Galli B, Horst R, Truitt GA, Uskoković MR, 1989

Effects of vitamin D derivatives on soft tissue calcification in neonatal and calcium mobilization in adult rats., Arch Toxicol 63: 394-400
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1988

Goff JP, Horst RL, Beitz DC, Littledike ET., 1988

Use of 24-F-1,25-dihydroxyvitamin D3 to prevent parturient paresis in dairy cows., J Dairy Sci 71: 1211-9
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Hoy DA, Ramberg CF Jr, Horst RL, 1988

Evidence that discrimination against ergocalciferol by the chick is the result of enhanced metabolic clearance rates for its mono- and dihydroxylated metabolites., J Nutr 118: 633-8
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Hustmyer FG, Nonnecke BJ, Beitz DC, et al. 1988

1,25-Dihydroxyvitamin D3 enhancement of concanavalin-A induced bovine lymphocyte proliferation: requirement of monocytes., Biochem Biophys Res Commun 152: 545-51
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1987

Engstrom GW, Goff JP, Horst RL, Reinhardt TA, 1987

Regulation of calf renal 25-hydroxyvitamin D-hydroxylase activities by calcium-regulating hormones., J Dairy Sci 70: 2266-71
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Klein GL, Sedman AB, Heyman MB, et al. 1987

Hepatic abnormalities associated with aluminum loading in piglets., JPEN J Parenter Enteral Nutr 11: 293-7
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1986

Engstrom GW, Reinhardt TA, Horst RL, 1986

25-Hydroxyvitamin D3-23-hydroxylase, a renal enzyme in several animal species., Arch Biochem Biophys 250: 86-93
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Goff JP, Horst RL, Littledike ET, et al. 1986

Bone resorption, renal function and mineral status in cows treated with 1,25-dihydroxycholecalciferol and its 24-fluoro analogues., J Nutr 116: 1500-10
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Horst RL, Reinhardt TA, Ramberg CF, et al. 1986

24-Hydroxylation of 1,25-dihydroxyergocalciferol. An unambiguous deactivation process., J Biol Chem 261: 9250-6
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Hedstrom OR, Cheville NF, Horst RL, 1986

Pathology of vitamin D deficiency in growing turkeys., Vet Pathol 23: 485-98
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Rosol TJ, Capen CC, Weisbrode SE, Horst RL, 1986

Humoral hypercalcemia of malignancy in nude mouse model of a canine adenocarcinoma derived from apocrine glands of the anal sac. Biochemical, histomorphometric, and ultrastructural studies., Lab Invest 54: 679-88
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Horst RL, 1986

Regulation of calcium and phosphorus homeostasis in the dairy cow., J Dairy Sci 69: 604-16
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Hines TG, Horst RL, Littledike ET, et al. 1986

Regulation of calcium and phosphorus homeostasis in the dairy cow., J Dairy Sci 69: 604-16
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1985

Wong KM, Klein L, Hollis B, 1985

Effects of parathyroid hormone on puppies during development of Ca and vitamin D deficiency., Am J Physiol 249: E568-76
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McDermott CM, Beitz DC, Littledike ET, Horst RL., 1985

Effects of dietary vitamin D3 on concentrations of vitamin D and its metabolites in blood plasma and milk of dairy cows., J Dairy Sci 68: 1959-67
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Engstrom GW, Horst RL, Reinhardt TA, Littledike ET, 1985

Effect of dietary phosphorus levels on porcine renal 25-hydroxyvitamin D-1 alpha- and 24R-hydroxylase activities and plasma 1,25-dihydroxyvitamin D3 concentration., J Anim Sci 60: 1005-11
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1984

Lester GE, Horst RL, Napoli JL., 1984

Formation of 19-nor-10-keto-25-hydroxyvitamin D3 in cultured mammalian cells., Biochem Biophys Res Commun 120: 919-25
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Hove K, Horst RL, Littledike ET, Beitz DC, 1984

Infusions of parathyroid hormone in ruminants: hypercalcemia and reduced plasma 1,25-dihydroxyvitamin D concentrations., Endocrinology 114: 897-903
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Goodman WG, Henry DA, Horst R, Nudelman RK, Alfrey AC, Coburn JW, 1984

Parenteral aluminum administration in the dog: II. Induction of osteomalacia and effect on vitamin D metabolism., Kidney Int 25: 370-5
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Engstrom GW, Horst RL, Reinhardt TA, Littledike ET, 1984

25-Hydroxyvitamin D 1 alpha- and 24-hydroxylase activities in pig kidney homogenates: effect of vitamin D deficiency, J Nutr 114: 119-26
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Goff JP, Horst RL, Littledike ET, 1984

Effect of sow vitamin D status at parturition on the vitamin D status of neonatal piglets., J Nutr 114: 163-9
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Bikle DD, Halloran BP, Whitney JO, Hollis BW., 1984

Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group., Biochemistry 23: 6920-5
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1983

Sommerfeldt JL, Napoli JL, Littledike ET, et al. 1983

Metabolism of orally administered [3H]ergocalciferol and [3H]cholecalciferol by dairy calves., J Nutr 113: 2595-600
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Horst RL, Hove K, Littledike ET, et al. 1983

Plasma concentrations of 1,25-dihydroxyvitamin D, 1,24R,25-trihydroxyvitamin D3, and 2,25,26-trihydroxyvitamin D3 after their administration to dairy cows., J Dairy Sci 66: 1455-60
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Horst RL, Reinhardt TA, 1983

Vitamin D metabolism in ruminants and its relevance to the periparturient cow., J Dairy Sci 66: 661-78
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Horst RL, Hove K, Littledike ET, et al. 1983

Plasma concentrations of 1,25-dihydroxyvitamin D, 1,24R,25-trihydroxyvitamin D3, and 2,25,26-trihydroxyvitamin D3 after their administration to dairy cows., J Dairy Sci 66: 1455-60
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Horst RL, Reinhardt TA, Pramanik BC, Napoli JL, 1983

23-Keto-25-hydroxyvitamin D3: a vitamin D3 metabolite with high affinity for the 1,25-dihydroxyvitamin D specific cytosol receptor, Biochemistry 22: 245-50
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Hove K, Horst RL, Littledike ET, 1983

Effects of 1 alpha-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, 1,24,25-trihydroxyvitamin D3, and 1,25,26-trihydroxyvitamin D3 on mineral metabolism and 1,25-dihydroxyvitamin D concentrations in dairy cows., J Dairy Sci 66: 59-66
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1982

Horst RL, Jorgensen NA, 1982

Elevated plasma cortisol during induced and spontaneous hypocalcemia in ruminants., J Dairy Sci 65: 2332-7
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Littledike ET, Horst RL, 1982

Metabolism of vitamin D3 in nephrectomized pigs given pharmacological amounts of vitamin D3., Endocrinology 111: 2008-13
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Goff JP, Horst RL, Littledike ET, 1982

Effect of the maternal vitamin D status at parturition on the vitamin D status of the neonatal calf., J Nutr 112: 1387-93
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Littledike ET, Horst RL, 1982

Vitamin D3 toxicity in dairy cows., J Dairy Sci 65: 749-59
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Horst RL, Napoli JL, Littledike ET, 1982

Discrimination in the metabolism of orally dosed ergocalciferol and cholecalciferol by the pig, rat and chick., Biochem J 204: 185-9
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Kichura TS, Horst RL, Beitz DC, Littledike ET, 1982

Relationships between prepartal dietary calcium and phosphorus, vitamin D metabolism, and parturient paresis in dairy cows., J Nutr 112: 480-7
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Horst RL, Littledike ET, 1982

Comparison of plasma concentrations of vitamin D and its metabolites in young and aged domestic animals., Comp Biochem Physiol B 73: 485-9
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1981

Reinhardt TA, Napoli JL, Praminik B, et al. 1981

1 Alpha-25,26-trihydroxyvitamin D3: an in vivo and in vitro metabolite of vitamin D3., Biochemistry 20: 6230-5
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Cheville NF, Horst RL, 1981

Pathology of experimental vitamin D deficiency in chickens and effects of treatment with vitamin D metabolites., Vet Pathol 18: 638-51
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Barton BA, Horst RL, Jorgensen NA, DeLuca HF, 1981

Concentration of calcium, phosphorus, and 1,25-dihydroxyvitamin D in plasma of dairy cows during the lactation cycle., J Dairy Sci 64: 850-2
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Green HB, Horst RL, Beitz DC, Littledike ET, 1981

Vitamin D metabolites in plasma of cows fed a prepartum low-calcium diet for prevention of parturient hypocalcemia., J Dairy Sci 64: 217-26
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Horst RL, Littledike ET, Gray RW, Napoli JL, 1981

Impaired 24,25-dihydroxyvitamin D production in anephric human and pig., J Clin Invest 67: 274-80
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1980

Horst RL, Littledike ET, 1980

25-OHD3-26,23 lactone: demonstration of kidney-dependent synthesis in the pig and rat., Biochem Biophys Res Commun 93: 149-54
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Philbrick DJ, Hollis BW, Draper HH, 1980

Effects of protein deficiency on plasma levels of 25-hydroxyvitamin and 24,25-dihydroxyvitamin D in the rat., Am J Clin Nutr 33: 2174-6
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1979

Horst RL, Littledike ET, 1979

Assay for vitamin D2 and vitamin D3 in plasma of dairy cows: changes after massive dosing of vitamin D3., J Dairy Sci 62: 1746-51
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Horst RL, 1979

25-OHD3-26,23-lactone: a metabolite of vitamin D3 that is 5 times more potent than 25-OHD3 in the rat plasma competitive protein binding radioassay., Biochem Biophys Res Commun 89: 286-93
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Gast DR, Horst RL, Jorgensen NA, DeLuca HF, 1979

Potential use of 1,25-dihydroxycholecalciferol for prevention of parturient paresis., J Dairy Sci 62: 1009-13
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Horst RL, Shepard RM, Jorgensen NA, DeLuca HF, 1979

93. Horst RL, Shepard RM, Jorgensen NA, DeLuca HF. The determination of the vitamin D metabolites on a single plasma sample: changes during parturition in dairy cows., Arch Biochem Biophys 192: 512-23
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1978

Horst RL, Jorgensen NA, DeLuca HF, 1978

Plasma 1,25-dihydroxyvitamin D and parathyroid hormone levels in paretic dairy cows., Am J Physiol 235: E634-7
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Jorgensen NA, Horst RL, DeLuca HF, Ogilvie ML, 1978

25-hydroxycholecalciferol for prevention of "milk fever" in dairy cows., Vet Rec 103: 136-8
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1977

Horst RL, Eisman JA, Jorgensen NA, DeLuca HF, 1977

Adequate response of plasma 1,25-dihydroxyvitamin D to parturition in paretic (milk fever) dairy cows., Science 196: 662-3
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Hollis BW, Hibbs JW, Conrad HR, 1977

Vitamin D binding factors in bovine blood., J Dairy Sci 60: 1605-11
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Hollis BW, Conrad HR, Hibbs JW, 1977

Changes in plasma 25-hydroxycholecalciferol and selected blood parameters after injection of massive doses of cholecalciferol or 25-hydroxycholecalciferol in non-lactating dairy cows., J Nutr 107: 606-13
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1976

Hollis BW, Conrad HR, 1976

Measurement of 25-hydroxycholecalciferol in the bovine., J Dairy Sci 59: 152204
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